Description
Product Characteristics: In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,LONP2,LONP,LONPL,PLON,PSLON,Cell Biology & Developmental Biology,Ubiquitin,LONP2
Target Information: mitochondrial ATP-dependent protease that displays increased expression under conditions of brain ischemia, hypoxia, and ER stress [RGD, Feb 2006]